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This Concept Map, created with IHMC CmapTools, has information related to: LAB 17 - SEROLOGY, PART 2 - INDIRECT SEROLOGIC TESTING, indirect serologic testing examples The RPR test for syphilis, indirect serologic testing general procedure A sample of the patient's serum is mixed with the known antigen for that suspected disease., antigen chemical nature large molecular weight proteins and polysaccharides, serology types direct serologic testing, indirect serologic testing examples The western blot test for HIV infection, qualitative test description Only detects the presence or absence of specific antibodies in the patient's serum and is often used for screening purposes., immunogen definition An antigen that is recognized by the body as nonself and stimulates an adaptive immune response., indirect serologic testing description Used to detect antibodies being made against a specific antigen in the patient's serum. Antibodies in a person's serum being made by that individual against an antigen associated with a particular disease are detected using a known antigen., direct serologic testing description Used to identify unknown antigens (such as microorganisms). A preparation known antibodies, called antiserum, is used to identify an unknown antigen., epitope definition The actual portions of an antigen that react with receptors on B-lymphocytes and T-lymphocytes, as well as with free antibody molecules; 5-15 amino acids, 3-4 sugar residues., large molecular weight proteins and polysaccharides examples microbial structures, microbial exotoxins, allergens, foreign tissues and cells, the body's own cells that the body fails to recognize as "normal self", serology definitions humoral immunity, indirect serologic testing examples Serologic test for infectious mononucleosis, antigen chemical nature immunogen, Used to detect antibodies being made against a specific antigen in the patient's serum. Antibodies in a person's serum being made by that individual against an antigen associated with a particular disease are detected using a known antigen. types quantitative test, The RPR test for syphilis description A presumptive serologic screening test for syphilis. Detects a non-specific anti-lipid antibody (traditionally termed reagin), which is not found in normal serum but is found in the serum of people with syphilis and several other diseases. The patient's serum is mixed with several known lipids bound to charcoal particles. Agglutination is positive., humoral immunity definition The production of antibody molecules in response to an antigen; mediated by B-lymphocytes., quantitative test description A quantitative test gives the titer of that antibody in the serum., The FTA-ABS test for syphilis description A confirming test for syphilis. Detects antibodies made against Treponema pallidum.The patient's serum is mixed with known T. pallidum on a microscope slide. If the test is positive, the spirochetes will fluoresce when viewed with a fluorescent microscope., serology definitions immunogen
