WARNING:
JavaScript is turned OFF. None of the links on this concept map will
work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: Answers_SIRS_Septic_Shock, vasodilation and increased capillary permeability results in Acute Respiratory Distress Syndrome (ARDS), peptidoglycan, LPS, porins, mannose, lipoteichoic acids, mycolic acid, bacterial and viral genomes, flagellin, etc. function as Pathogen-Associated Molecular Patterns (PAMPs), neutrophils attach to capillary walls during diapedesis discharge lysosomes extracellular killing by neutrophils damages tissues, inflammatory cytokines (IL-1, IL-8, TNF-alpha NO, etc.) triggers overproduction of nitric oxide (NO), Pattern-Recognition Receptors (PRRs) on macrophages, dendritic cells, and other cells. leads to synthesis and release of inflammatory cytokines (IL-1, IL-8, TNF-alpha NO, etc.), drop in blood glucose levels leads to decreased cellular metabolism, clots (microthrombi) form in capillaries causes Disseminated Intravascular Coagulation (DIC), hemorrhages contributes to hypovolemia, extracellular killing by neutrophils damages blood vessel walls result blood leaks into surrounding tissues, vasodilation and increased capillary permeability causes plasma leakage into surrounding tissue, heart failure contributes to Multiple Organ System Failure (MOSF), increase in neutrophil numbers diapedesis neutrophils attach to capillary walls during diapedesis, clots (microthrombi) form in capillaries leads to decreased clotting factors, kidney damage contributes to Multiple Organ System Failure (MOSF), decreased myocardial contractility contributes to heart failure, inflammatory cytokines (IL-1, IL-8, TNF-alpha NO, etc.) leads to increase in neutrophil numbers, end-organ ischemia leads to impaired liver function, decreased cellular metabolism contributes to Multiple Organ System Failure (MOSF), Disseminated Intravascular Coagulation (DIC) contributes to hypoperfusion, hypoperfusion significance without oxygen, cells switch to fermentation and produce acid end products
