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This Concept Map, created with IHMC CmapTools, has information related to: Answers_type I toxins, Production of other cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), inflammatory chemokines such as IL-8, and platelet-activating factor (PAF) examples Streptococcal pyrogenic exotoxin (Spe), Superantigens are unusual bacterial toxins that interact with and activate exceedingly large numbers of T4-lymphocytes. conventional antigen Are engulfed by antigen presenting cells (APCs), degraded into epitopes, bind to the peptide groove of MHC-II molecules, and are put on the surface of the APC. Here they are recognized by specific T4-lymphocytes having a T-cell receptor (TCR) with a corresponding shape., Toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus, ETEC enterotoxin produced by enterotoxogenic Escherichia cili (ETEC), Production of other cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), inflammatory chemokines such as IL-8, and platelet-activating factor (PAF) examples ETEC enterotoxin, Are engulfed by antigen presenting cells (APCs), degraded into epitopes, bind to the peptide groove of MHC-II molecules, and are put on the surface of the APC. Here they are recognized by specific T4-lymphocytes having a T-cell receptor (TCR) with a corresponding shape. results The APC activates the T4-lymphocyte with a corresponding T-cell receptor., Streptococcal pyrogenic exotoxin (Spe) produced by Streptococcus pyogenes, Bind directly to the outside of MHC-II molecules and activate large numbers of T4-lymphocytes results Activate as many as 1 in 5 T-lymphocytes, Production of other cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), inflammatory chemokines such as IL-8, and platelet-activating factor (PAF) examples Toxic shock syndrome toxin-1 (TSST-1), Superantigens are unusual bacterial toxins that interact with and activate exceedingly large numbers of T4-lymphocytes. superantigen Bind directly to the outside of MHC-II molecules and activate large numbers of T4-lymphocytes, Type I toxins (superantigens) description Superantigens are unusual bacterial toxins that interact with and activate exceedingly large numbers of T4-lymphocytes., Staphylococcus aureus can lead to Streptococcus pyogenes, Staphylococcus aureus can lead to systemic inflammatory response syndrome (SIRS), Bind directly to the outside of MHC-II molecules and activate large numbers of T4-lymphocytes results Secretion of excessive amounts of the cytokine interleukin-2 (IL-2) as well as the activation of self-reactive T-lymphocytes, Are engulfed by antigen presenting cells (APCs), degraded into epitopes, bind to the peptide groove of MHC-II molecules, and are put on the surface of the APC. Here they are recognized by specific T4-lymphocytes having a T-cell receptor (TCR) with a corresponding shape. results Normally results in the activation of maybe 1 in 10,000 T-lymphcytes., Secretion of excessive amounts of the cytokine interleukin-2 (IL-2) as well as the activation of self-reactive T-lymphocytes leads to Production of other cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), inflammatory chemokines such as IL-8, and platelet-activating factor (PAF)
