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This Concept Map, created with IHMC CmapTools, has information related to: Blanks_enzyme_regulation, example The lac operon. Lactose functions as an inducer., mechanism The inhibitor is the end product of an enzymatic reaction. That end product is also capable of reacting with the enzyme's active site and prevents the enzyme from binding its normal substrate. As a result, the end product is no longer synthesized., types of repressors, Activators are regulatory proteins that promote transcription of mRNA. mechanism Activators control genes that have a promotor to which RNA polymerase cannot bind. The activator is an allosteric protein synthesized in a form that cannot normally bind to the activator-binding site. Binding of an inducer to the activator now enables it to bind to the activator-binding site., The lac operon. Lactose functions as an inducer. lactose is present When lactose, the inducer, is present, it binds to the allosteric repressor protein and causes it to change shape in such a way that it is no longer able to bind to the operator. Now RNA polymerase can transcribe the three genes required for the degradation of lactose and the bacterium is able to synthesize the enzymes needed for its utilization., Involves the induction or repression of enzyme synthesis by regulatory proteins that can bind to DNA and either block or enhance the function of RNA polymerase, the enzyme required for transcription. operon A set of genes transcribed as a polycistronic message that is collectively controlled by a regulatory protein., Involves the induction or repression of enzyme synthesis by regulatory proteins that can bind to DNA and either block or enhance the function of RNA polymerase, the enzyme required for transcription. translational control of enzyme synthesis The bacteria produce antisense RNA that is complementary to the mRNA coding for the enzyme., ENZYME REGULATION general mechanisms Controlling the Enzyme's Activity (Feedback Inhibition)., Involves the induction or repression of enzyme synthesis by regulatory proteins that can bind to DNA and either block or enhance the function of RNA polymerase, the enzyme required for transcription. activation of enzyme synthesis Activators are regulatory proteins that promote transcription of mRNA., mechanism The inhibitor is the end product of a metabolic pathway that is able to bind to a second site (the allosteric site) on the enzyme. Binding of the inhibitor to the allosteric site alters the shape of the enzyme's active site thus preventing binding of the first substrate in the metabolic pathway. In this way, the pathway is turned off., Involves the induction or repression of enzyme synthesis by regulatory proteins that can bind to DNA and either block or enhance the function of RNA polymerase, the enzyme required for transcription. repression of enzyme synthesis Repressors are regulatory proteins that block transcription of mRNA., Activators control genes that have a promotor to which RNA polymerase cannot bind. The activator is an allosteric protein synthesized in a form that cannot normally bind to the activator-binding site. Binding of an inducer to the activator now enables it to bind to the activator-binding site. inducer is present, The lac operon. Lactose functions as an inducer. lactose is absent In the absence of lactose, the repressor protein binds to the operator and RNA polymerase is unable to get beyond the operator and transcribe the genes for utilization of lactose and the three enzymes for degradation of lactose are not synthesized., The trp operon. Tryptophan funsction as a corepressor. tryptophan is present, ENZYME REGULATION general mechanisms Genetic Control of Enzyme Synthesis, Controlling the Enzyme's Activity (Feedback Inhibition). types, Genetic Control of Enzyme Synthesis description Involves the induction or repression of enzyme synthesis by regulatory proteins that can bind to DNA and either block or enhance the function of RNA polymerase, the enzyme required for transcription., example The trp operon. Tryptophan funsction as a corepressor., Controlling the Enzyme's Activity (Feedback Inhibition). types, The trp operon. Tryptophan funsction as a corepressor. tryptophan is absent
