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This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antibiotic_Modeofaction, macrolides action prevents peptidyltransferase from forming peptide bonds, inhibit synthesis of acid-fast cell walls examples ethambutol, antibiotic/chemical agent inhibits normal nucleic acid replication examples fluoroquinolones, puts nicks in the DNA strands of certain bacteria result blocks the replication of bacterial DNA, binds to 50S ribosomal subunit examples streptogramins, prevents peptidyltransferase from forming peptide bonds ???? inhibits elongation of the protein, antibiotic/chemical agent inhibits normal nucleic acid replication examples metronidazole, binds to 30S ribosomal subunit examples tetracyclines, no glycosidic or peptide bonds form; weak cell wall result osmotic lysis, antibiotics and chemical agents affect bacterial structures or functions. mode of action inhibit synthesis of acid-fast cell walls, inhibits elongation of the protein result blocks translation of mRNA into protein, binds to 50S ribosomal subunit examples oxazolidinones, binds to 30S ribosomal subunit examples aminoglycosides, bacitracin action binds to bactoprenol, interferes with the binding of the 50S subunit to the initiation complex result blocks translation of mRNA into protein, aminoglycosides action prevents the transfer of the peptidyl tRNA from the A-site to the P-site, fluoroquinolones action inhibits bacterial topoisomerase enzymes, antibiotic/chemical agent binds to prokaryotic ribosomal subunits ???? binds to 50S ribosomal subunit, antibiotics and chemical agents affect bacterial structures or functions. mode of action antibiotic/chemical agent binds to prokaryotic ribosomal subunits, prevents the transfer of the peptidyl tRNA from the A-site to the P-site ???? preventing the elongation of the polypeptide chain
