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This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antiviral agents, HIV nucleoside-analog reverse transcriptase inhibitors action Chemically resemble a normal DNA nucleoside. Once inserted into the growing DNA chain it inhibits further proviral production, fomivirsen (Vitravene) mode of action A microRNA that has a nucleotide sequence complementary to a sequence in mRNA transcripts that encodes several proteins responsible for production of infectious CMV. Binding of fomivirsen to the target mRNA results in inhibition of viral protein synthesis., HIV nucleoside-analog reverse transcriptase inhibitors examples zidovudine (AZT; ZDV; Retrovir); didanosine (ddI; dideoxyinosine; Videx); stavudine (d4T; Zerit); lamivudine (3TC; Epivir); abacavir (ABC; Ziagen); emtricitabine (FTC; Emtriva, Coviracil), HIV mode of action HIV Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs), Antiviral Agents used to treat HIV, HIV mode of action HIV Protease Inhibitors (PIs), Integrase Inhibitors example raltegravir (Isentress), influenza viruses examples zanamivir (Relenza); oseltamivir (Tamiflu), hepatitis C virus (HCV) examples telaprevir (Incivek); boceprevir (Victrelis), amantadine (Symmetrel); rimantidine (Flumadine) mode of action blocks the uncoating step blocking viral replication, lamivudine (Epivir-HBV); adefovir dipivoxil (Hepsera) mode of action Chemically resemble a normal DNA nucleoside. Once inserted into the growing DNA chain it inhibits further viral DNA replication., Antiviral Agents used to treat herpes simplex viruses (HSV); varicella zoster virus (VZV), HIV Protease Inhibitors (PIs) examples saquinavir (SQV; Inverase); ritonavir (RTV; Norvir); idinavir (IDV; Crixivan); nelfinavir (NFV; Viracept); amprenavir (APV; Agenerase); atazanavir (ATV; Reyataz); fosamprenavir (FPV; Lexiva); ritonavir (RTV; Norvir) darunavir (DRV; TMC114; Prezista); tipranavir (TPV; Aptivus), HIV mode of action Integrase Inhibitors, Antiviral Agents used to treat influenza viruses, Antiviral Agents used to treat hepatitis C virus (HCV), telaprevir (Incivek); boceprevir (Victrelis) mode of action A protease inhibitor that binds to an HCV-encoded protease and prevents it from cleaving the long polyprotein from polycistronic HCV genes into proteins essential to the structure and function of HCV., acyclovir (Zovirax); famciclovir (Famvir); valacyclovir (Valtrex); penciclovir (Denavir); mode of action Chemically resemble a normal DNA nucleoside. Once inserted into the growing DNA chain it inhibits further viral DNA replication., cytomegaloviruses (CMV) examples gancyclovir (Cytovene; Vitrasert); valganciclovir (Valcyte); foscarnet (Foscavir); cidofovir (Vistide), influenza viruses examples amantadine (Symmetrel); rimantidine (Flumadine)
Illustration of ganciclovir
nimation of normal function of an allosteric enzyme
Animation of an inhibitor binding to the allosteric site of an enzyme
Illustration of zidovudine
Animation of normal action of an HIV protease
Animation of the action of an HIV protease inhibitor
Animation of transcription of DNA from thr HIV RNA genome
Animation of the action of zidovudine
Illustration of the action ofmaraviroc
Illustration of ganciclovir
