WARNING:
JavaScript is turned OFF. None of the links on this concept map will
work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antiviral agents, HIV mode of action Entry Inhibitors (EIs), HIV Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) action Bind to an allosteric site that regulates reverse transcriptase activity rather than to the enzyme's active site; inhibits proviral production, Integrase Inhibitors action Binds to HIV integrase, the enzyme that inserts the HIV double-stranded DNA intermediate into host cell DNA, fomivirsen (Vitravene) mode of action A microRNA that has a nucleotide sequence complementary to a sequence in mRNA transcripts that encodes several proteins responsible for production of infectious CMV. Binding of fomivirsen to the target mRNA results in inhibition of viral protein synthesis., hepatitis C virus (HCV) examples telaprevir (Incivek); boceprevir (Victrelis); simeprevir (Olysio), remdesivir experimental Remdesivir (GS-5734™) is authorized for use under an EUA only for the treatment of patients with suspected or laboratory-confirmed SARS-CoV-2 infection and severe COVID-19. It appears to speed up recovery time of severe COVID-19 infections by several days as well as slightly lower the death rate., HIV mode of action HIV Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs), Antiviral Agents used to treat cytomegaloviruses (CMV), remdesivir mode of action Remdesivir is a nucleoside analog that resembles an adenine ribonucleotide. Once RNA-dependant RNA polymerase inserts remdesivir into the rowing RNA strand it terminates RNA synthesis., lamivudine (Epivir-HBV); adefovir dipivoxil (Hepsera) mode of action Chemically resemble a normal DNA nucleoside. Once inserted into the growing DNA chain it inhibits further viral DNA replication., telaprevir (Incivek); boceprevir (Victrelis); simeprevir (Olysio) mode of action A protease inhibitor that binds to an HCV-encoded protease and prevents it from cleaving the long polyprotein from polycistronic HCV genes into proteins essential to the structure and function of HCV., hepatitis B virus (HBV) examples lamivudine (Epivir-HBV); adefovir dipivoxil (Hepsera), amantadine (Symmetrel); rimantidine (Flumadine) mode of action blocks the uncoating step blocking viral replication, enfuvirtide (ENF; T-20; Fuzeon) action Binds to gp41 and blocks the fusion of the viral envelope with the cytoplasmic membrane of the host cell, Antiviral Agents used to treat HIV, gancyclovir (Cytovene; Vitrasert); valganciclovir (Valcyte); foscarnet (Foscavir); cidofovir (Vistide) mode of action Chemically resemble a normal DNA nucleoside. Once inserted into the growing DNA chain it inhibits further viral DNA replication., Antiviral Agents used to treat herpes simplex viruses (HSV); varicella zoster virus (VZV), HIV mode of action Integrase Inhibitors, hepatitis C virus (HCV) examples sofosbuvir (Sovaldi), ribavirin (Copegus; Rebetol; Virazole) mode of action Chemically resemble a normal RNA nucleoside. Once inserted into the growing RNA chain it inhibits further viral RNA replication.
