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This Concept Map, created with IHMC CmapTools, has information related to: blank_NK and iNKT cells, The cell has low levels of stress molecules and high levels of MHC-I molecules. final result, mechanisms used by NK cells to bind to and kill target cells, invarient natural killer T-lymphocytes (iNKT Cells) development of normal iNKT cell responses Microbes the human body has been traditionally exposed to from early childhood throughout most of human history might play a role in developing normal iNKT cell numbers and iNKT cell responses., apoptosis NK cells bind to the IgG after it has bound to foreign antigens on infected cells and tumor cells and induce apoptosis., MHC-I molecules MHC-I/peptide complexs on infected and tumor cells bind to receptors on cytotoxic T-lymphocytes or CTLs. If the MHC-I molecules have peptides from the body's own proteins bound to them, CTLs do not recognize those cells as foreign and the cell is not killed. If, on the other hand, the MHC-I molecules have peptides from viral, bacterial, or mutant proteins bound to them, CTLs recognize that cell as foreign and kill that cell., Granzymes pass through the pores and activate the caspase enzymes that lead to apoptosis of the infected cell. caspase enzymes, mechanisms used by NK cells to bind to and kill target cells, Various stress-induced molecules are produced and are put on the surface of that cell. killer-ihibitory receptor, invarient natural killer T-lymphocytes (iNKT Cells) activation of iNKT cell, mechanism Various stress-induced molecules are produced and are put on the surface of that cell., Rapidly produce large quantities of cytokines, including interferon-gamma (IFN-γ), interleukin-4 (IL-4), interleukin-2 (IL-2), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), interleukin-13 (IL-13), and chemokines. functions of cytokines, apoptosis, invarient natural killer T-lymphocytes (iNKT Cells) activation of iNKT cell Also activated by the cytokine interleukin-12 (IL-12) produced by activated macrophages., then NK cells bind to the IgG after it has bound to foreign antigens on infected cells and tumor cells and induce apoptosis., scenario The cell has low levels of stress molecules and high levels of MHC-I molecules., granzymes Granzymes pass through the pores and activate the caspase enzymes that lead to apoptosis of the infected cell., Rapidly produce large quantities of cytokines, including interferon-gamma (IFN-γ), interleukin-4 (IL-4), interleukin-2 (IL-2), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), interleukin-13 (IL-13), and chemokines. functions of cytokines Essential in both innate and adaptive immune protection against pathogens and tumors., Various stress-induced molecules are produced and are put on the surface of that cell. killer-activating receptor, Also activated by the cytokine interleukin-12 (IL-12) produced by activated macrophages. results of activation, natural killer (NK) cells functions Produce a variety of cytokines, including proinflammatory cytokines, chemokines, colony-stimulating factors, and other cytokines that function as regulators of body defenses.
