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This Concept Map, created with IHMC CmapTools, has information related to: blanks_nutiimm_fever_acutephase, Intraepithelial T-lymphocytes and B-1 Cells ???? Intraepithelial T-lymphocytes (IELs); known as gamma:delta T-lymphocytes, Nutritional Immunity function, Nutritional Immunity, Fever, the Acute Phase Response, and Intraepithelial T-Lymphocytes and B-1 Cells ???? Nutritional Immunity, mechanisms prior stationing of lactoferrin at common sites of microbial invasion such as in the mucous of mucous membranes, Acute Phase Response initiated by PAMPs binding to PRRs stimulate the production of inflammatory cytokines., functions of CRP functions as an opsonin, sticking the microorganism to phagocytes, PAMPs binding to PRRs stimulate the production of inflammatory cytokines. inflammatory cytokines, mechanisms increased synthesis of the human iron-binding proteins (iron chelators) such as lactoferrin, transferrin, ferritin, and hemin that trap iron for use by human cells while making it unavailable to most microbes, inflammatory cytokines stimulate the anterior hypothalamus of the brain to produce prostaglandin E2, which leads to an increase bodily heat production and increased vasoconstriction, benefit Iron is needed as a cofactor for certain microbial enzyme reactions., Intraepithelial T-lymphocytes (IELs); known as gamma:delta T-lymphocytes functions aid in repair of mucous membranes following inflammatory damage, examples of acute phase proteins, Intraepithelial T-lymphocytes (IELs); known as gamma:delta T-lymphocytes functions, inflammatory cytokines, mechanisms, Intraepithelial T-lymphocytes (IELs); known as gamma:delta T-lymphocytes locations, B-1 lymphocytes (B-1 cells) locations, Fever benefits increases the environmental temperature above the optimum growth temperature for many microorganisms, Fever benefits, mechanisms decreased ability of bacteria to synthesize their own iron chelators called siderophores
