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This Concept Map, created with IHMC CmapTools, has information related to: Answers_ clonal selection_memory, Clonal Selection, Clonal Expansion, and Memory clonal selection Each naive T4-lymphocyte becomes genetically programmed to make a T-cell receptor (TCR) with a unique specificity. Identical molecules of that TCR are placed on its surface where they are able to bind an epitope/MHC-II complex on an antigen-presenting dendritic cell with a corresponding shape., Each B-lymphocyte becomes genetically programmed to make an antibody with a unique antigen-binding site (Fab) through a series of gene translocations, and molecules of that antibody are put on its surface to function as the B-cell receptor. process When an antigen encounters the immune system, its epitopes eventually will react with a naive B-lymphocyte with B-cell receptors on its surface that more or less fit and this activates that B-lymphocyte., When an antigen encounters the immune system, its epitopes eventually will react with a naive T4-lymphocyte with T-cell receptors on its surface that more or less fit and this activates that T4-lymphocyte. clonal expansion In response to cytokines, these activated T4-lymphocytes now rapidly proliferate to produce large clones of thousands of identical T4-lymphocytes., Numerous circulating T4-memory cells develop which possess anamnestic response or memory. subsequent exposure to the same antigen More T4-effector cells are produced in greater amounts for a longer period of time., Clonal Selection, Clonal Expansion, and Memory clonal selection Each B-lymphocyte becomes genetically programmed to make an antibody with a unique antigen-binding site (Fab) through a series of gene translocations, and molecules of that antibody are put on its surface to function as the B-cell receptor., Cytokines produced by effector T4-helper lymphocytes enable the now activated B-lymphocyte to rapidly proliferate to produce large clones of thousands of identical B-lymphocytes. differentiation Eventually these variant B-lymphocytes differentiate into plasma cells that synthesize and secrete vast quantities of antibodies that have Fab sites which fit the original epitope., Eventually these variant B-lymphocytes differentiate into plasma cells that synthesize and secrete vast quantities of antibodies that have Fab sites which fit the original epitope. systemic infection and vaccination Many of the plasma cells migrate to the bone marrow where they may continue to secrete antibodies for months or years after the antigen has been eliminated., More antibodies are produced in greater amounts for a longer period of time. secondary anamnestic response peaks in only 1 - 3 days, When an antigen encounters the immune system, its epitopes eventually will react with a naive B-lymphocyte with B-cell receptors on its surface that more or less fit and this activates that B-lymphocyte. clonal expansion Cytokines produced by effector T4-helper lymphocytes enable the now activated B-lymphocyte to rapidly proliferate to produce large clones of thousands of identical B-lymphocytes., In response to cytokines, these activated T4-lymphocytes now rapidly proliferate to produce large clones of thousands of identical T4-lymphocytes. differentiation Eventually this clone of T4-lymphocytes differentiates into effector T4-lymphocytes, Eventually this clone of T4-lymphocytes differentiates into effector T4-lymphocytes memory Numerous circulating T4-memory cells develop which possess anamnestic response or memory., Eventually these variant B-lymphocytes differentiate into plasma cells that synthesize and secrete vast quantities of antibodies that have Fab sites which fit the original epitope. infection of mucous membranes Plasma cells produced in the mucous membranes generally remain in the mucous membranes and secrete antibodies for only around a year., Numerous circulating B-memory cells develop which possess anamnestic response or memory. subsequent exposure to the same antigen More antibodies are produced in greater amounts for a longer period of time., Eventually these variant B-lymphocytes differentiate into plasma cells that synthesize and secrete vast quantities of antibodies that have Fab sites which fit the original epitope. memory Numerous circulating B-memory cells develop which possess anamnestic response or memory., Eventually these variant B-lymphocytes differentiate into plasma cells that synthesize and secrete vast quantities of antibodies that have Fab sites which fit the original epitope. time span It generally takes 4-5 days for a naive B-lymphocyte that has been activated to complete clonal expansion and differentiate into effector B-lymphocytes., More antibodies are produced in greater amounts for a longer period of time. primary response to a new antigen generally peaks at 5 - 10 days., Each naive T4-lymphocyte becomes genetically programmed to make a T-cell receptor (TCR) with a unique specificity. Identical molecules of that TCR are placed on its surface where they are able to bind an epitope/MHC-II complex on an antigen-presenting dendritic cell with a corresponding shape. process When an antigen encounters the immune system, its epitopes eventually will react with a naive T4-lymphocyte with T-cell receptors on its surface that more or less fit and this activates that T4-lymphocyte.
