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This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antibody_Protection, Ways In Which Antibodies Protect The Body method Opsonization (enhanced attachment), Fab of IgG binds to epitopes of antigen; Fc portion binds to receptors on phagocytes. engulfment and destruction extracellular destruction, Fab of IgE binds to epitopes of helminths; Fc portion binds to receptors on eosinophils. mechanism The eosinophil empties the contents of its lysosomes directly on the helminth., Ways In Which Antibodies Protect The Body method MAC cytolysis, to block microbial motility mechanism Fab of antibody binds to microbial flagella or cilia, to cause apoptosis if infected cells and cancer cells mechanism Fab of IgG binds to epitopes of foreign cell; Fc portion binds to receptors on NK cells., Membrane-Attack Complex (MAC) damages membrane or envelope viral envelope damage to viral envelope; incomplete virion, IgG or IgM activate the classical complement pathway; C3b and C4b bind microbe or cell to the phagocyte. mechanism Microorganisms are placed in phagosomes where they are ultimately digested by lysosomes., Inflammation is the means by which body defense cells (such as phagocytes, CTLs, and NK cells) and defense chemicals (such as complement proteins, antibodies, clotting factors, defensins, and lysozyme) leave the blood and enter the tissue around the injured or infected site. production of IgE can bind to mast cells and basophils and trigger the release of inflammatory mediators, to prevent bacteria from adhering to host cell receptors mechanism Fab of antibody binds to adhesin, adhesive tip of pilus, or to glycocalyx, Fab of antibody binds to adhesin, adhesive tip of pilus, or to glycocalyx result Bacteria cannot adhere to host cell and are flushed away., Ways In Which Antibodies Protect The Body method Agglutination of microorganisms, Fab of IgG binds to epitopes of antigen; Fc portion binds to receptors on phagocytes. engulfment and destruction intracellular destruction, Fab of antibody binds to microbial flagella or cilia result bacterium or protozoan cannot penetrate mucus to reach mucosal epithelium, Fab of IgG binds to the binding portion of the exotoxin result exotoxin cannot bind to host cell receptor and enter host cell, MAC cytolysis purpose to activate the classical complement pathway and enable MAC lysis of membrane-bound cells and viral envelopes, Fab of IgG binds to epitopes of foreign cell; Fc portion binds to receptors on NK cells. result NK cell releases perforins and granzymes to trigger apoptosis of infected cell or cancer cell., to activate the classical complement pathway and enable MAC lysis of membrane-bound cells and viral envelopes mechanism Fab of IgG or IgM binds to epitopes on a gram-negative bacterium, a membrane-bound cell, or a viral envelope; Fc portion activates the classical complement pathway., Ways In Which Antibodies Protect The Body method Immobilization of bacteria and protozoans, Fab of IgG or IgM binds to epitopes on a gram-negative bacterium, a membrane-bound cell, or a viral envelope; Fc portion activates the classical complement pathway. result Membrane-Attack Complex (MAC) damages membrane or envelope