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This Concept Map, created with IHMC CmapTools, has information related to: Answers_MHC, antigens that enter from outside the body examples protozoa, proteins found within the cytosol of human cells examples proteins that have escaped into the cytosol from the phagosome of phagocytes, peptide epitopes from exogenous antigens exogenous antigen antigens that enter from outside the body, MHC-II molecules function enable T4-lymphocytes to recognize epitopes of antigens, MHC-II molecules bind bind peptide epitopes from endogenous antigens through cross-presentation by certain dendritic cells, MHC-I molecules function enable T8-lymphocytes to recognize epitopes of antigens; enable the body to recognize infected cells and tumor cells and destroy them with cytotoxic T-lymphocytes (CTLs), MHC-II molecules bind peptide epitopes from exogenous antigens, antigens that enter from outside the body processing of exogenous antigens Microbes are engulfed and placed in a phagosome and degraded by lysosomes. Proteases degrade microbial proteins into peptides that are then attached to MHC-II molecules., MHC-I molecules made by all nucleated cells in the body, proteins found within the cytosol of human cells examples self-peptides from host cellular proteins, antigen-presenting cells or APCs examples of APCs dendritic cells, macrophages, and B-lymphocytes, MHC-I molecules bind bind peptide epitopes from endogenous antigens, MHC molecules enable T-lymphocytes to recognize epitopes of antigens. because T-cell receptors (TCRs) of T-lymphocytes can only recognize epitopes after they are bound to MHC molecules., antigens that enter from outside the body examples bacteria, proteins found within the cytosol of human cells examples proteins produced by intracellular bacteria, MHC Molecules function MHC molecules enable T-lymphocytes to recognize epitopes of antigens., MHC-II molecules made by antigen-presenting cells or APCs, MHC Molecules class MHC-II molecules, bind peptide epitopes from exogenous antigens through cross-presentation by certain dendritic cells exogenous antigens antigens that enter from outside the body, MHC-I molecules present MHC-I/peptide complexes to a complementary-shaped TCR/CD8 on the surface of naive T8-lymphocytes and cytotoxic T-lymphocytes
