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This Concept Map, created with IHMC CmapTools, has information related to: Answers_antibody isotypes, IgG (Immunoglobulin G; 4 subclasses, IgG1-4) characteristics Fc portion can bind to receptors on phagocytes for opsonization, IgA (Immunoglobulin A; 2 subclasses, IgA1-2) characteristics Fc portion of secretory IgA can bind to macrophages and neutrophils, Antibody Isotypes definition of antibody Antibodies or immunoglobulins are specific glycoprotein configurations produced by B-lymphocytes and plasma cells in response to a specific antigen and capable of reacting with that antigen., IgG (Immunoglobulin G; 4 subclasses, IgG1-4) characteristics can cross the placenta, IgG (Immunoglobulin G; 4 subclasses, IgG1-4) characteristics makes up approximately 80% of the serum antibodies, IgM (Immunoglobulin M) characteristics found mainly in the bloodstream rather than in the intracellular spaces of tissues where it can control infections in the blood, Antibody Isotypes classes or isotypes of human antibodies (immunoglobulins IgE (Immunoglobulin E), IgA (Immunoglobulin A; 2 subclasses, IgA1-2) characteristics appears as a dimer of 2 "Y"-shaped molecules and has 4 epitope-binding sites, IgA (Immunoglobulin A; 2 subclasses, IgA1-2) characteristics found mainly in body secretions (saliva, mucous, tears, colostrum and milk) where it protects internal body surfaces exposed to the environment by blocking the attachment of bacteria and viruses to mucous membranes, IgG (Immunoglobulin G; 4 subclasses, IgG1-4) characteristics Fc portion can activate the classical complement pathway, IgD: (Immunoglobulin D) characteristics found on the surface of B-lymphocytes (along with monomeric IgM) as a B-cell receptor, IgM (Immunoglobulin M) characteristics Fc portions are able to activate the classical complement pathway, IgD: (Immunoglobulin D) characteristics makes up approximately 0.2% of the serum antibodies, IgM (Immunoglobulin M) characteristics makes up 13% of the serum antibodies; is the first antibody produced during an immune response, IgG (Immunoglobulin G; 4 subclasses, IgG1-4) characteristics has 2 epitope-binding sites, IgM (Immunoglobulin M) characteristics monomeric forms are found on the surface of B-lymphocytes as B-cell receptors, IgE (Immunoglobulin E) characteristics is a monomer and has 2 epitope-binding sites, IgM (Immunoglobulin M) characteristics is a pentamer and has 10 epitope-binding sites, Antibody Isotypes classes or isotypes of human antibodies (immunoglobulins IgA (Immunoglobulin A; 2 subclasses, IgA1-2), Antibody Isotypes classes or isotypes of human antibodies (immunoglobulins IgG (Immunoglobulin G; 4 subclasses, IgG1-4)