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This Concept Map, created with IHMC CmapTools, has information related to: Blanks_PRRs, mannan-binding lectin binds to, binds specifically to conserved portion of PAMPs and DAMPs PAMPs Pathogen-Associated Molecular Patterns, examples NODs, signaling PRRs found on cell surfaces general function, inflammatory cytokines examples interleukin-12 (IL-12), activation of genes coding for inflammatory cytokines benefit migration of leukocytes and defense chemicals from the blood to the infected site, viral RNA molecules results in synthesis of interferons, dectin-1 binds to beta-glucans (polymer of glucose), commonly found in fungal cell walls, location of signaling PRRs signaling PRRs found in the membranes of endosomes (phagolysosomes), benefits, soluble molecules produced a s result of the body's immune defenses that bind microbes to phagocytes (opsonization) examples mannose-binding lectin (MBL), binds to bacterial flagellin, promotes the production of, inflammatory cytokines examples, soluble molecules produced a s result of the body's immune defenses that bind microbes to phagocytes (opsonization) examples, CARD-containing proteins RIG-1, MDA-5 binds to viral RNA molecules, promotes the production of antiviral cytokines called type-1 interferons (IFN), examples N-formyl Met receptors, antiviral cytokines called type-1 interferons (IFN) examples IFN-alpha, inflammatory cytokines examples
