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This Concept Map, created with IHMC CmapTools, has information related to: MYO_General Steps_Adaptive_Immunity, The large clones of identical B-lymphocytes, T4-lymphocytes, and T8-lymphocytes now differentiate into effector cells capable of directing body defenses against the original antigen resulting in its destruction or neutralization. Step 5 Some of the B-lymphocytes, T4-lymphocytes, and T8-lymphocytes differentiate into long-lived, circulating memory cells., The antigen must encounter the B-lymphocytes, T-lymphocytes, and antigen-presenting cells (APCs) capable of carrying out an adaptive immune response. Step 2 Naive B-lymphocytes and naive T4-lymphocytes must recognize epitopes of an antigen by means of antigen-specific receptor molecules on their surface and become activated. This is known as clonal selection., Naive B-lymphocytes and naive T4-lymphocytes must recognize epitopes of an antigen by means of antigen-specific receptor molecules on their surface and become activated. This is known as clonal selection. Step 3 After the naive B-lymphocytes, T4-lymphocytes, and T8-lymphocytes bind their corresponding epitopes, they must proliferate into large clones of identical cells in order to mount a successful immune response against that antigen. This is known as clonal expansion., General Steps in an Adaptive Immune Response Step 1 The antigen must encounter the B-lymphocytes, T-lymphocytes, and antigen-presenting cells (APCs) capable of carrying out an adaptive immune response., After the naive B-lymphocytes, T4-lymphocytes, and T8-lymphocytes bind their corresponding epitopes, they must proliferate into large clones of identical cells in order to mount a successful immune response against that antigen. This is known as clonal expansion. Step 4 The large clones of identical B-lymphocytes, T4-lymphocytes, and T8-lymphocytes now differentiate into effector cells capable of directing body defenses against the original antigen resulting in its destruction or neutralization.