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This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antibody_Protection, Promoting inflammation IgA can activate the lectin pathway and alternative complement pathway, Fab of antibody binds to adhesin, adhesive tip of pilus, or to glycocalyx result Bacteria cannot adhere to host cell and are flushed away., Fab of IgG binds to the binding portion of the exotoxin result exotoxin cannot bind to host cell receptor and enter host cell, Fab of IgG binds to epitopes of foreign cell; Fc portion binds to receptors on NK cells. result NK cell releases perforins and granzymes to trigger apoptosis of infected cell or cancer cell., Ways In Which Antibodies Protect The Body method MAC cytolysis, Promoting inflammation IgE can bind to mast cells and basophils and trigger the release of inflammatory mediator, Fab of IgG binds to epitopes of antigen; Fc portion binds to receptors on phagocytes. engulfment and destruction engulfment of encapsulated microorganisms, Fab of antibody binds to the attachment site of the virus. result Virus cannot bind to host cell receptor. Therefore, it cannot penetrate or replicate within the host cell., to prevent bacteria from adhering to host cell receptors mechanism Fab of antibody binds to adhesin, adhesive tip of pilus, or to glycocalyx, Ways In Which Antibodies Protect The Body method Neutralization of a virus, Fab of antibody binds to microbial flagella or cilia result bacterium or protozoan cannot penetrate mucus to reach mucosal epithelium, can bind to mast cells and basophils and trigger the release of inflammatory mediator benefits delivers defense molecules and defense cells to the infected site, to clump microbes together for easier phagocytosis and mechanical removal mechanism Fab of IgM and IgA clumps microbes together, to prevent exotoxins from binding to host cell receptors mechanism Fab of IgG binds to the binding portion of the exotoxin, can activate the lectin pathway and alternative complement pathway benefits inflammation (C5a, C3a, C4a), chemotaxis of phagocytes (C5a), opsonization (C3b, C4b), MAC lysis of membranes, Ways In Which Antibodies Protect The Body method Preventing bacterial adherence, to enable opsonins such as IgG and IgE, as well as complement proteins such as C3b, C4b to attach microbes or cells to phagocytes C3b, C4b IgG or IgM activate the classical complement pathway; C3b and C4b bind microbe or cell to the phagocyte., Ways In Which Antibodies Protect The Body method Promoting inflammation, to enable opsonins such as IgG and IgE, as well as complement proteins such as C3b, C4b to attach microbes or cells to phagocytes IgE Fab of IgE binds to epitopes of helminths; Fc portion binds to receptors on eosinophils., Agglutination of microorganisms purpose to clump microbes together for easier phagocytosis and mechanical removal
