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This Concept Map, created with IHMC CmapTools, has information related to: Answers_SARS-CoV-2, adsorption ???? The S1 subunit of the S protein binds to the human ACE-2 enzyme (angiotensin-converting enzyme 2)., Severe Acute Respiratory Syndrome Coronavirus-2 or SARS-CoV-2 viral structure nucleocapsid, N proteins bind to viral RNA genomes to form viral nucleocapsids which then bind to the ERGICs and are pulled in forming the viral envelope embedded with S, M, and E proteins . next The intact viruses are then packaged in smooth secretion vesicles by the Golgi where they are released from the host cell by exocytosis., Severe Acute Respiratory Syndrome Coronavirus-2 or SARS-CoV-2 viral structure envelope derived from host cell membranes, viral penetration ???? The virus enters by endocytosis and is placed in an endosome. S2 subunit of S protein triggers the fusion of the viral envelope with the membrane of the endosome and the viral nucleocapsid enters the host cell's cytoplasm., Small subgenomic mRNAs coding for the N protein are translated by cytoplasmic ribosomes where they then bind to the genomic (+) ss RNAs to form viral nucleocapsids. Small subgenomic mRNAs coding for viral structural protein such as the S, M, and E proteins are translated at the ribosomes of the rough endoplasmic reticulum (ER) where they enter the ER. maturation ER then packages these proteins and transports them to the Golgi by way of ER-Golgi intermediate compartments (ERGIC) containing the S, M, and E proteins., viral penetration next genome replication and production of viral mRNAs, nucleocapsid N or nucleocapsid protein Structurally is bound to RNA genome. involved in various processes related to viral replication., envelope derived from host cell membranes envelope proteins E or envelope protein, genome replication and production of viral mRNAs ???? RNA-dependent RNA polymerase copiesy the sense (+) RNA genome producing antisense ss (-) RNA. RNA-dependent RNA polymerase enzymes then copies the antisense (-) RNA strands producing copies of the sense ss (+) RNA viral genomes., Many small subgenomic RNA strands enable transcription of several subgenomic mRNAs of varying length coding for various viral proteins such as S, M, E, and N proteins. maturation Small subgenomic mRNAs coding for the N protein are translated by cytoplasmic ribosomes where they then bind to the genomic (+) ss RNAs to form viral nucleocapsids. Small subgenomic mRNAs coding for viral structural protein such as the S, M, and E proteins are translated at the ribosomes of the rough endoplasmic reticulum (ER) where they enter the ER., Small subgenomic mRNAs coding for the N protein are translated by cytoplasmic ribosomes where they then bind to the genomic (+) ss RNAs to form viral nucleocapsids. Small subgenomic mRNAs coding for viral structural protein such as the S, M, and E proteins are translated at the ribosomes of the rough endoplasmic reticulum (ER) where they enter the ER. N proteins ????, adsorption next viral penetration, RNA-dependent RNA polymerase copiesy the sense (+) RNA genome producing antisense ss (-) RNA. RNA-dependent RNA polymerase enzymes then copies the antisense (-) RNA strands producing copies of the sense ss (+) RNA viral genomes. nucleocapsid formation N proteins bind to viral RNA genomes to form viral nucleocapsids which then bind to the ERGICs and are pulled in forming the viral envelope embedded with S, M, and E proteins ., nucleocapsid genome plus, single-stranded RNA; functions both as the gemome and as mRNA., ER then packages these proteins and transports them to the Golgi by way of ER-Golgi intermediate compartments (ERGIC) containing the S, M, and E proteins. maturation N proteins bind to viral RNA genomes to form viral nucleocapsids which then bind to the ERGICs and are pulled in forming the viral envelope embedded with S, M, and E proteins ., Coronaviruses: Enveloped single-stranded RNA viruses examples Severe Acute Respiratory Syndrome Coronavirus-2 or SARS-CoV-2, Coronaviruses: Enveloped single-stranded RNA viruses examples Severe Acute Respiratory Syndrome Coronavirus or SARS-CoV, envelope derived from host cell membranes envelope proteins S or spike protein, M or membrane protein function Central organizer for coronavirus assembly.
