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This Concept Map, created with IHMC CmapTools, has information related to: Answers_Cytokines_PAMPs_PRRs, disseminated intravascular coagulation (DIC) result plugs capillaries, delivers defense cells and defense chemicals to the infection site examples antibodies, defensins, lysozyme, etc., extracellular killing by neutrophils results in blood and plasma leaves blood and enters tissue, decreased vascular resistance causes hypotension, hypovolemia leads to hypoperfusion, high levels of cell wall PAMPs are released and bind to PRRs on defense cells results in excessive activation of coagulation pathway, excessive production of complement pathway proteins harmful effects excessive inflammation, hypotension leads to hypoperfusion, blood and plasma leaves blood and enters tissue causes acute respiratory distress syndrome (ARDS), acidosis results stops metabolic enzyme reactions, excessive inflammation results excessive inflammation, low levels of cell wall PAMPs are released and bind to PRRs on defense cells results in moderate activation of the coagulation pathway, low levels of cell wall PAMPs are released and bind to PRRs on defense cells results in moderate production of complement pathways proteins, acute respiratory distress syndrome (ARDS) leads to lungs can't oxygenate the blood, Pattern-Recognition Receptors (PRRs) on macrophages, dendritic cells, and other cells. pyroptosis Pyroptosis is a programmed inflammatory death of host cells that is mediated by an enzyme called caspase 1 and can be triggered by a variety of stimuli, including pathogen-associated molecular patterns (PAMPs) from microbial infections, as well as danger-associated molecular patterns (DAMPs) produced as a result of tissue injury during cancer, heart attack, and stroke., plasma leaves blood and enters tissue causes hypovolemia, prolonged vasodilation results in decreased vascular resistance, promotes body defense by stimulating an inflammatory response results in vasodilation and diapedesis, high levels of cell wall PAMPs are released and bind to PRRs on defense cells results in excessive production of complement pathway proteins, Pyroptosis is a programmed inflammatory death of host cells that is mediated by an enzyme called caspase 1 and can be triggered by a variety of stimuli, including pathogen-associated molecular patterns (PAMPs) from microbial infections, as well as danger-associated molecular patterns (DAMPs) produced as a result of tissue injury during cancer, heart attack, and stroke. results in Pyroptosis results in production of proinflammatory cytokines, rupture of the cell’s plasma membrane, and subsequent release of proinflammatory intracellular contents.
