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This Concept Map, created with IHMC CmapTools, has information related to: Answers_SIRS_Septic_Shock, vasodilation and increased capillary permeability results in Acute Respiratory Distress Syndrome (ARDS), peptidoglycan, LPS, porins, mannose, lipoteichoic acids, mycolic acid, bacterial and viral genomes, flagellin, etc. function as Pathogen-Associated Molecular Patterns (PAMPs), neutrophils attach to capillary walls during diapedesis discharge lysosomes extracellular killing by neutrophils damages tissues, Pattern-Recognition Receptors (PRRs) on macrophages, dendritic cells, and other cells. leads to synthesis and release of inflammatory cytokines (IL-1, IL-8, TNF-alpha NO, etc.), inflammatory cytokines (IL-1, IL-8, TNF-alpha NO, etc.) triggers overproduction of nitric oxide (NO), drop in blood glucose levels leads to decreased cellular metabolism, vasodilation and increased capillary permeability causes plasma leakage into surrounding tissue, extracellular killing by neutrophils damages blood vessel walls result blood leaks into surrounding tissues, hemorrhages contributes to hypovolemia, clots (microthrombi) form in capillaries causes Disseminated Intravascular Coagulation (DIC), heart failure contributes to Multiple Organ System Failure (MOSF), increase in neutrophil numbers diapedesis neutrophils attach to capillary walls during diapedesis, decreased myocardial contractility contributes to heart failure, kidney damage contributes to Multiple Organ System Failure (MOSF), clots (microthrombi) form in capillaries leads to decreased clotting factors, end-organ ischemia leads to impaired liver function, inflammatory cytokines (IL-1, IL-8, TNF-alpha NO, etc.) leads to increase in neutrophil numbers, Disseminated Intravascular Coagulation (DIC) contributes to hypoperfusion, decreased cellular metabolism contributes to Multiple Organ System Failure (MOSF), blood leaks into surrounding tissues contributes to hypovolemia
