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This Concept Map, created with IHMC CmapTools, has information related to: Answers_autoimmunity, The Ability to Induce Autoimmune Responses description When the body's immune defenses mistakenly attack the body. (Sometimes induced by bacterial infections), When the body's immune defenses mistakenly attack the body. (Sometimes induced by bacterial infections) mechanisms Inducing the production of cross-reacting antibodies and possibly auto-reactive cytotoxic T-lymphocytes or CTLs, Tertiary syphilis results in Heart damage, neurological abnormalities, and distructive skin lesion, When the body's immune defenses mistakenly attack the body. (Sometimes induced by bacterial infections) other examples Tertiary syphilis, Tertiary syphilis caused by Treponema pallidum, Rheumatic fever caused by Rheumatogenic strains of Streptococcus pyogenes, Inducing the production of cross-reacting antibodies and possibly auto-reactive cytotoxic T-lymphocytes or CTLs significance Antibodies and CTLs made in response to bacterial antigens accidently cross react with epitopes on host cells, Chronic Lyme disease results in Arthritis, neurological abnormalities, and heart damage, When the body's immune defenses mistakenly attack the body. (Sometimes induced by bacterial infections) other examples Chronic Lyme disease, Antibodies and CTLs made in response to bacterial antigens accidently cross react with epitopes on host cells results Destroys the host cells to which they have bound, Rheumatogenic strains of Streptococcus pyogenes mechanism Antibodies and CTLs stimulated by antigens of S. pyogenes cross-react with heart and joint tissues damaging the heart and joints., Stimulating the production of soluble immune antigen-antibody complexes significance Immune complexes can lodge in filtering units such as the kidneys where they activate the complement pathway, When the body's immune defenses mistakenly attack the body. (Sometimes induced by bacterial infections) mechanisms Stimulating the production of soluble immune antigen-antibody complexes, Chronic Lyme disease caused by Borrelia burgdorferi, Stimulating the production of soluble immune antigen-antibody complexes example acute glomerulonephritis, acute glomerulonephritis caused by Streptococcus pyogenes, Inducing the production of cross-reacting antibodies and possibly auto-reactive cytotoxic T-lymphocytes or CTLs example Rheumatic fever, Immune complexes can lodge in filtering units such as the kidneys where they activate the complement pathway results The resulting inflammatory response can destroys kidney tissues.
