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This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antiviral agents, HIV mode of action HIV Protease Inhibitors (PIs), amantadine (Symmetrel); rimantidine (Flumadine) mode of action blocks the uncoating step blocking viral replication, HIV Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) examples evirapine (NVP; Viramune); delavirdine (DLV;Rescriptor); efavirenz (EFV; Sustiva); rilpivirine (Edurant); etravirine (ETR, TMC125; Intelence), fomivirsen (Vitravene) mode of action A microRNA that has a nucleotide sequence complementary to a sequence in mRNA transcripts that encodes several proteins responsible for production of infectious CMV. Binding of fomivirsen to the target mRNA results in inhibition of viral protein synthesis., influenza viruses examples zanamivir (Relenza); oseltamivir (Tamiflu), hepatitis B virus (HBV) examples lamivudine (Epivir-HBV); adefovir dipivoxil (Hepsera), telaprevir (Incivek); boceprevir (Victrelis); simeprevir (Olysio); sofosbuvir (Sovaldi) mode of action A protease inhibitor that binds to an HCV-encoded protease and prevents it from cleaving the long polyprotein from polycistronic HCV genes into proteins essential to the structure and function of HCV., Antiviral Agents used to treat influenza viruses, HIV mode of action HIV Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs), Entry Inhibitors (EIs) example maraviroc (MVC; Selzentry; Celsentri), acyclovir (Zovirax); famciclovir (Famvir); valacyclovir (Valtrex); penciclovir (Denavir); mode of action Chemically resemble a normal DNA nucleoside. Once inserted into the growing DNA chain it inhibits further viral DNA replication., HIV mode of action Entry Inhibitors (EIs), Entry Inhibitors (EIs) example enfuvirtide (ENF; T-20; Fuzeon), Integrase Inhibitors example raltegravir (Isentress), hepatitis C virus (HCV) examples telaprevir (Incivek); boceprevir (Victrelis); simeprevir (Olysio); sofosbuvir (Sovaldi), Integrase Inhibitors action Binds to HIV integrase, the enzyme that inserts the HIV double-stranded DNA intermediate into host cell DNA, HIV nucleoside-analog reverse transcriptase inhibitors action Chemically resemble a normal DNA nucleoside. Once inserted into the growing DNA chain it inhibits further proviral production, zanamivir (Relenza); oseltamivir (Tamiflu) mode of action inhibitors of the enzyme called neuraminidase required for release of newly formed viruses from the infected cell, HIV Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) action Bind to an allosteric site that regulates reverse transcriptase activity rather than to the enzyme's active site; inhibits proviral production, hepatitis C virus (HCV) examples ribavirin (Copegus; Rebetol; Virazole)
