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This Concept Map, created with IHMC CmapTools, has information related to: Answers_SARS-CoV-2, envelope derived from host cell membranes envelope proteins S or spike protein, S or spike protein function S1 subunit is responsible for virus binding to ACE-2 enzyme during viral adsorption. S2 subunit is responsible for viral envelope-host cell membrane fusion during viral entry into the host cell., genome replication and production of viral mRNAs ???? RNA-dependent RNA polymerase copiesy the sense (+) RNA genome producing antisense ss (-) RNA. RNA-dependent RNA polymerase enzymes then copies the antisense (-) RNA strands producing copies of the sense ss (+) RNA viral genomes., adsorption next viral penetration, RNA-dependent RNA polymerase enzymes copy the antisense (-) RNA strand into (+) viral mRNAs. The (+) viral mRNA can then be translated into viral proteins by host cell ribosomes. formation of double-membrane replication organelles Interactions between various nsps and host cell factors also initiate the formation of double-membrane replication organelles derived from the endoplasmic reticulum of the host cell. These double-membrane enclosures for the viral dsRNA are thought to create a protective microenvironment for viral genomic RNA replication and transcription of subgenomic mRNAs (sg mRNAs) of SARS-CoV-2., Severe Acute Respiratory Syndrome Coronavirus-2 or SARS-CoV-2 viral structure nucleocapsid, nucleocapsid N or nucleocapsid protein Structurally is bound to RNA genome. involved in various processes related to viral replication., Many small subgenomic RNA strands enable transcription of several subgenomic mRNAs of varying length coding for various viral proteins such as S, M, E, and N proteins. maturation Small subgenomic mRNAs coding for the N protein are translated by cytoplasmic ribosomes where they then bind to the genomic (+) ss RNAs to form viral nucleocapsids. Small subgenomic mRNAs coding for viral structural protein such as the S, M, and E proteins are translated at the ribosomes of the rough endoplasmic reticulum (ER) where they enter the ER., Coronaviruses: Enveloped single-stranded RNA viruses examples Severe Acute Respiratory Syndrome Coronavirus or SARS-CoV, Severe Acute Respiratory Syndrome Coronavirus-2 or SARS-CoV-2 viral replication adsorption, genome replication and production of viral mRNAs ???? RNA-dependent RNA polymerase enzymes copy the antisense (-) RNA strand into (+) viral mRNAs. The (+) viral mRNA can then be translated into viral proteins by host cell ribosomes., Severe Acute Respiratory Syndrome Coronavirus-2 or SARS-CoV-2 viral structure envelope derived from host cell membranes, viral penetration next genome replication and production of viral mRNAs, Coronaviruses: Enveloped single-stranded RNA viruses examples Severe Acute Respiratory Syndrome Coronavirus-2 or SARS-CoV-2, Coronaviruses: Enveloped single-stranded RNA viruses examples Middle East Respiratory Syndrome Coronavirus or MERS-CoV, ER then packages these proteins and transports them to the Golgi by way of ER-Golgi intermediate compartments (ERGIC) containing the S, M, and E proteins. maturation N proteins bind to viral RNA genomes to form viral nucleocapsids which then bind to the ERGICs and are pulled in forming the viral envelope embedded with S, M, and E proteins ., adsorption ???? The S1 subunit of the S protein binds to the human ACE-2 enzyme (angiotensin-converting enzyme 2)., RNA-dependent RNA polymerase enzymes copy the antisense (-) RNA strand into (+) viral mRNAs. The (+) viral mRNA can then be translated into viral proteins by host cell ribosomes. translation of viral mRNAs Many small subgenomic RNA strands enable transcription of several subgenomic mRNAs of varying length coding for various viral proteins such as S, M, E, and N proteins., E or envelope protein function Plays a role in the production, maturation, and release of this virus., viral penetration ???? May also enter by fusion of the viral envelope with the host cell plasma membrane as a result of the S2 subunit.
