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This Concept Map, created with IHMC CmapTools, has information related to: Answers_PRRs, mannan-binding lectin binds to carbohydrates on bacteria, yeasts, some viruses, and some parasites, binds specifically to conserved portion of PAMPs and DAMPs PAMPs Pathogen-Associated Molecular Patterns, signaling PRRs found in the cytoplasm examples NODs, signaling PRRs found on cell surfaces general function stimulate the transcription and translation of inflammatory cytokines, inflammatory cytokines examples interleukin-12 (IL-12), activation of genes coding for inflammatory cytokines benefit migration of leukocytes and defense chemicals from the blood to the infected site, viral RNA molecules results in synthesis of interferons, dectin-1 binds to beta-glucans (polymer of glucose), commonly found in fungal cell walls, signaling pattern-recognition receptors location of signaling PRRs signaling PRRs found in the membranes of endosomes (phagolysosomes), stimulate the transcription and translation of inflammatory cytokines benefits migration of leukocytes and defense chemicals from the blood to the infected site, soluble molecules produced a s result of the body's immune defenses that bind microbes to phagocytes (opsonization) examples mannose-binding lectin (MBL), TLR-5 binds to bacterial flagellin, signaling pattern-recognition receptors promotes the production of chemotactic factors such as chemokines, inflammatory cytokines examples interleukin-1 (IL-1), soluble molecules produced a s result of the body's immune defenses that bind microbes to phagocytes (opsonization) examples the antibody molecule IgG, CARD-containing proteins RIG-1, MDA-5 binds to viral RNA molecules, signaling pattern-recognition receptors promotes the production of antiviral cytokines called type-1 interferons (IFN), endocytic pattenn-recognition receptors examples N-formyl Met receptors, antiviral cytokines called type-1 interferons (IFN) examples IFN-alpha, inflammatory cytokines examples tumor necrosis factor-alpha (TNF-alpha)
