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This Concept Map, created with IHMC CmapTools, has information related to: Answers_complement_pathways, C5b binds to the target cell and subsequently binds C6, C7, C8, and a number of monomers of C9 to form C5b6789n, the Membrane Attack Complex (MAC) benefit lysis of membrane-bound cells, Fab of IgG or IgM binds to epitopes of an antigen finally C1q,C1r, and C1s assemble on Fc portion of antibodies forming the first enzyme, C1, C3b binds to antigen as an opsonin benefit enhanced attachment of antigen to phagocytes, C5a is a chemoattractant for phagocytes benefit C5a is a chemoattractant for phagocytes, cleaves C2 into C2a and C2b; cleaves C4 into C4a and C4b function C4b binds to antigen as an opsonin, C4b and C2a combine to form C3 convertase then C3 convertase splits C3 molecules into C3a and C3b, C5b binds to the target cell and subsequently binds C6, C7, C8, and a number of monomers of C9 to form C5b6789n, the Membrane Attack Complex (MAC) benefit lysis of membrane-bound cells, C3 convertase splits C3 molecules into C3a and C3b function C3a triggers inflammation, factor B combines with the cell-bound C3b to form C3bB then factor D splits factor B into Bb and Ba, forming C3bBb, C3 convertase splits C3 molecules into C3a and C3b then C3b binds to the C3bBb to form C3bBb3b, a C5 convertase, C4b and C2a join to form a C3 convertase then C3 convertase splits C3 molecules into C3a and C3b, factor D splits factor B into Bb and Ba, forming C3bBb finally properdin then binds to the Bb to form C3bBbP that functions as a C3 convertase, The Complement Pathways type the lectin pathway, C3 convertase splits C3 molecules into C3a and C3b function C3b binds to antigen as an opsonin, activated C1 enzymatically cleaves C4 into C4a and C4b function C4a triggers inflammation, C5 convertase splits C5 molecules into C5a and C5b finally C5b binds to the target cell and subsequently binds C6, C7, C8, and a number of monomers of C9 to form C5b6789n, the Membrane Attack Complex (MAC), properdin then binds to the Bb to form C3bBbP that functions as a C3 convertase then C3 convertase splits C3 molecules into C3a and C3b, The Complement Pathways type the classical complement pathway, MASP1 and MASP2 bind to MBL to form the first enzyme of the pathway then cleaves C2 into C2a and C2b; cleaves C4 into C4a and C4b, mannan-binding lectin (MBL) binds to the mannose groups of microbial carbohydrates then MASP1 and MASP2 bind to MBL to form the first enzyme of the pathway
