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This Concept Map, created with IHMC CmapTools, has information related to: answers_PRRs_DRRs, TLR-5 binds to bacterial flagellin, TLR-7 and TLR-8 binds to single-stranded viral RNA, TLR-3 binds to double-stranded viral RNA, Pattern-Recognition Receptors (PRRs) and Danger-Recognition Receptors (DRRs) types endocytic pattenn-recognition receptors, TLR-9 binds to unmethylated cytosine-guanine dinucleotide sequences (CpG DNA) found in bacterial and viral genomes, antiviral cytokines called type-1 interferons (IFN) examples IFN-beta, chemotactic factors such as chemokines examples MCP-1, signaling PRRs found in the cytoplasm examples CARD-containing proteins RIG-1, MDA-5, signaling PRRs found in the membranes of endosomes (phagolysosomes) examples TLR-7 and TLR-8, endocytic pattenn-recognition receptors examples scavenger receptors, endocytic pattenn-recognition receptors examples dectin-1, signaling pattern-recognition receptors location of signaling PRRs signaling PRRs found on cell surfaces, endocytic pattenn-recognition receptors examples N-formyl Met receptors, chemotactic factors such as chemokines examples RANTES, dectin-1 binds to beta-glucans (polymer of glucose), commonly found in fungal cell walls, signaling PRRs found in the membranes of endosomes (phagolysosomes) general function stimulate the synthesis of cytokines called interferons, signaling PRRs found in the membranes of endosomes (phagolysosomes) examples TLR-3, signaling pattern-recognition receptors promotes the production of antiviral cytokines called type-1 interferons (IFN), mannose receptors binds to microbial carbohydrates such as those rich in mannose or fucose, and N-acetylglucosamine (NAG), signaling PRRs found in the membranes of endosomes (phagolysosomes) examples TLR-9