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This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antibodies, IgA description Makes up approximately 6% of the serum antibodies., The simplest antibodies, such as IgG, IgD, and IgE, are "Y"-shaped macromolecules called monomers. A monomer is composed of four glycoprotein chains: two identical heavy chains and two identical light chains parts of an antibody molecule The bottom part of the "Y", the C terminal region of each glycoprotein chain, is called the Fc portion, The Fc portion is responsible for the biological activity of the antibody. examples of biological activity Activate the classical complement pathway (IgG & IgM), IgM description Fc portions of IgM are able to activate the classical complement pathway, IgG description Fc portion of IgG enables it to cross the placenta. IgG is the only class of antibody that can cross the placenta and enter the fetal circulation., IgD description Found on the surface of B-lymphocytes, along with monomeric IgM, as a B-cell receptor., IgG description Fc portion of IgG can bind to macrophage and neutrophils for opsonization., IgE description Makes up about 0.002% of the serum antibodies., IgA description Fc portion of secretory IgA can bind to macrophages and neutrophils for opsonization., The simplest antibodies, such as IgG, IgD, and IgE, are "Y"-shaped macromolecules called monomers. A monomer is composed of four glycoprotein chains: two identical heavy chains and two identical light chains ???? IgM is a pentamer consisting of 5 "Y"-like molecules connected at their Fc portions by a "J" or joining chain., ANTIBODIES (IMMUNOGLOBULINS 5 classes of human antibodies IgA, IgM description Monomeric forms of IgM are found on the surface of B-lymphocytes as B-cell receptors., IgE description Most IgE is tightly bound to basophils and mast cells via its Fc region., IgM description Makes up approximately 13% of the serum antibodies., ANTIBODIES (IMMUNOGLOBULINS 5 classes of human antibodies IgD, The bottom part of the "Y", the C terminal region of each glycoprotein chain, is called the Fc portion function The Fc portion is responsible for the biological activity of the antibody., The Fc portion is responsible for the biological activity of the antibody. examples of biological activity Activate the lectin complement pathway and the alternative complement pathway (IgA), IgM description Is the first antibody produced during an immune response., IgE description A monomer and has 2 epitope-binding sites., The Fc portion is responsible for the biological activity of the antibody. examples of biological activity Bind to receptors on phagocytes (IgG, IgA)
