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This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antibody_Protection, to enable opsonins such as IgG and IgE, as well as complement proteins such as C3b, C4b to attach microbes or cells to phagocytes IgG Fab of IgG binds to epitopes of antigen; Fc portion binds to receptors on phagocytes., can activate the classical complement pathway benefits inflammation (C5a, C3a, C4a), chemotaxis of phagocytes (C5a), opsonization (C3b, C4b), MAC lysis of membranes, Neutralization of a virus purpose to block viral adsorption to host cell, can bind to mast cells and basophils and trigger the release of inflammatory mediator benefits delivers defense molecules and defense cells to the infected site, Fab of antibody binds to adhesin, adhesive tip of pilus, or to glycocalyx result Bacteria cannot adhere to host cell and are flushed away., Fab of antibody binds to microbial flagella or cilia result bacterium or protozoan cannot penetrate mucus to reach mucosal epithelium, to prevent bacteria from adhering to host cell receptors mechanism Fab of antibody binds to adhesin, adhesive tip of pilus, or to glycocalyx, Fab of IgM and IgA clumps microbes together results microbes are phagocytosed or physically removed from the body, Preventing bacterial adherence purpose to prevent bacteria from adhering to host cell receptors, Ways In Which Antibodies Protect The Body method MAC cytolysis, Fab of IgG binds to epitopes of antigen; Fc portion binds to receptors on phagocytes. engulfment and destruction intracellular destruction, Opsonization (enhanced attachment) purpose to enable opsonins such as IgG and IgE, as well as complement proteins such as C3b, C4b to attach microbes or cells to phagocytes, Ways In Which Antibodies Protect The Body method Opsonization (enhanced attachment), Membrane-Attack Complex (MAC) damages membrane or envelope viral envelope damage to viral envelope; incomplete virion, Neutralization of exotoxins purpose to prevent exotoxins from binding to host cell receptors, Ways In Which Antibodies Protect The Body method Neutralization of exotoxins, Promoting inflammation IgA can activate the lectin pathway and alternative complement pathway, Antibody-Dependent Cellular Cytotoxicity (ADCC) by NK cells purpose to cause apoptosis if infected cells and cancer cells, Fab of IgG or IgM binds to epitopes on a gram-negative bacterium, a membrane-bound cell, or a viral envelope; Fc portion activates the classical complement pathway. result Membrane-Attack Complex (MAC) damages membrane or envelope, to enable opsonins such as IgG and IgE, as well as complement proteins such as C3b, C4b to attach microbes or cells to phagocytes IgE Fab of IgE binds to epitopes of helminths; Fc portion binds to receptors on eosinophils.
