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This Concept Map, created with IHMC CmapTools, has information related to: Answers_General Steps_Adaptive_Immunity, B-cell receptor (BCR) result activated B-lymphocytes, antibody-secreting B-lymphocytes and plasma cells benefits neutralization of exotoxins, macrophages benefit killing of ingested microbes, recognition of epitopes by naive T4-lymphocytes results in activation of naive T4-lymphocyte, T-independent antigens (large polysaccharides, lipids) types TI-2 antigens, such as capsular polysaccharides, the secondary lymphoid organs of the lymphoid system examples lymph nodules, antibody-secreting B-lymphocytes and plasma cells benefits ADCC by NK cells, TI-1 antigens are pathogen- associated molecular patterns (PAMPS) recognized by pattern-recognition receptors (PRRs), proliferation of B-lymphocytes differentiate into antibody-secreting B-lymphocytes and plasma cells, proliferation T4-lymphocytes and their differentiation into T4-effector cells T4 effector cells interact with activated B-lymphocytes, proliferation T4-lymphocytes and their differentiation into T4-effector cells examples of T4-effectors cells Th1 cells, Th1 cells activates macrophages, Th1 cells activates cytotoxic T-lymphocytes (CTLs), Naive B-lymphocytes and naive T4-lymphocytes must recognize epitopes of an antigen by means of antigen-specific receptor molecules on their surface and become activated. This is known as clonal selection. recognition of epitope role of antigen-presenting dendritic cells, Naive B-lymphocytes and naive T4-lymphocytes must recognize epitopes of an antigen by means of antigen-specific receptor molecules on their surface and become activated. This is known as clonal selection. recognition of epitope recognition of epitopes by naive B-lymphocytes, role of antigen-presenting dendritic cells uses MHC-II molecules recognition of epitopes by naive T4-lymphocytes, the secondary lymphoid organs of the lymphoid system examples MALT, GALT, SALT, NALT, antibody-secreting B-lymphocytes and plasma cells benefits neutralization of viruses, activated T8-lymphocyte leads to proliferation of T8 lymphocytes, proliferation of T8 lymphocytes differentiate into T8-memory cells