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This Concept Map, created with IHMC CmapTools, has information related to: Answers_MHC, antigen-presenting cells or APCs examples of APCs dendritic cells, macrophages, and B-lymphocytes, proteins found within the cytosol of human cells examples tumor antigens produced by cancer cells, antigens that enter from outside the body examples free viruses, bind peptide epitopes from endogenous antigens endogenous antigen proteins found within the cytosol of human cells, antigens that enter from outside the body processing of exogenous antigens Microbes are engulfed and placed in a phagosome and degraded by lysosomes. Proteases degrade microbial proteins into peptides that are then attached to MHC-II molecules., MHC Molecules class MHC-I molecules, antigens that enter from outside the body examples fungi, MHC Molecules function MHC molecules enable T-lymphocytes to recognize epitopes of antigens., proteins found within the cytosol of human cells processing of endogenous antigens Cytoplasmic viral, bacterial, or tumor proteins are degraded into peptide epitopes by organelles called proteasomes and attached to MHC-I molecules., MHC-II molecules function enable T4-lymphocytes to recognize epitopes of antigens, antigens that enter from outside the body examples protozoa, MHC-II molecules made by antigen-presenting cells or APCs, MHC-I molecules bind bind peptide epitopes from endogenous antigens, MHC-I molecules present MHC-I/peptide complexes to a complementary-shaped TCR/CD8 on the surface of naive T8-lymphocytes and cytotoxic T-lymphocytes, proteins found within the cytosol of human cells examples proteins produced by intracellular bacteria, antigens that enter from outside the body examples bacteria, MHC-II molecules bind peptide epitopes, typically 10-30 amino acids, long from exogenous antigens, proteins found within the cytosol of human cells examples self-peptides from host cellular proteins, MHC-I molecules made by all nucleated cells in the body, MHC-II molecules present MHC-II/peptide complexes to a complementary-shaped TCR/CD8 on the surface of naive T4-lymphocytes or effector T4-lymphocytes
Illustration of Binding of Peptide Epitopes from Exogenous Antigens to MHC-II Molecules
Animation showing MHC-II molecules binding epitopes from exogenous antigens
Animation showing a naive T4-lymphocyte recognizing epitopes bound to MHC-II molecules on an APC
Illustration of Binding of Peptide Epitopes from Endogenous Antigens to MHC-I Molecules by a Dendritic Cell
Animation showing MHC I molecules binding epitopes from endogenous antigens by an antigen presenting cell
animation showing a naive T8-lymphocyte recognizing epitopes bound to MHC-I molecules on an antigen-presenting dendritic cell
Illustration of Binding of Peptide Epitopes from Endogenous Antigens to MHC-I Molecules by a Virus-Infected Cell
Animation showing MHC-I molecules binding epitopes from endogenous antigens in an infected cell
Animation showing a CTL triggering apoptosis by way of perforins and granzymes
Animation showing CTL-induced apoptosis of a virus-infected cell
Epitope-Specific Receptors on the Surface of B- and T-Lymphocytes
Illustration of Binding of Peptide Epitopes from Endogenous Antigens to MHC-I Molecules by a Dendritic Cell
Animation showing MHC I molecules binding epitopes from endogenous antigens by an antigen presenting cell
animation showing a naive T8-lymphocyte recognizing epitopes bound to MHC-I molecules on an antigen-presenting dendritic cell
Illustration of Binding of Peptide Epitopes from Endogenous Antigens to MHC-I Molecules by a Dendritic Cell
Animation showing MHC I molecules binding epitopes from endogenous antigens by an antigen presenting cell
animation showing a naive T8-lymphocyte recognizing epitopes bound to MHC-I molecules on an antigen-presenting dendritic cell
Illustration of Binding of Peptide Epitopes from Endogenous Antigens to MHC-I Molecules by a Dendritic Cell
Animation showing MHC I molecules binding epitopes from endogenous antigens by an antigen presenting cell
animation showing a naive T8-lymphocyte recognizing epitopes bound to MHC-I molecules on an antigen-presenting dendritic cell
Illustration of Binding of Peptide Epitopes from Exogenous Antigens to MHC-II Molecules
Animation showing MHC-II molecules binding epitopes from exogenous antigens
Animation showing a naive T4-lymphocyte recognizing epitopes bound to MHC-II molecules on an APC
Illustration of Binding of Peptide Epitopes from Exogenous Antigens to MHC-II Molecules
Animation showing MHC-II molecules binding epitopes from exogenous antigens
Animation showing a naive T4-lymphocyte recognizing epitopes bound to MHC-II molecules on an APC
Illustration of Binding of Peptide Epitopes from Endogenous Antigens to MHC-I Molecules by a Dendritic Cell
Animation showing MHC I molecules binding epitopes from endogenous antigens by an antigen presenting cell
animation showing a naive T8-lymphocyte recognizing epitopes bound to MHC-I molecules on an antigen-presenting dendritic cell
