Animation of Phagocytosis by Unenhanced Attachment
(PAMPs Binding to Endocytic Pattern-Recognition Receptors)

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Unenhanced attachment is a general recognition of what are called pathogen-associated molecular patterns or PAMPs- components of common molecules such as peptidoglycan, teichoic acids, lipopolysaccharide, mannans, and glucans common in microbial cell walls but not found on human cells - by means of glycoproteins known as endocytic pattern-recognition receptors on the surface of the phagocytes. Following attachment, polymerization and then depolymerization of actin filaments send pseudopods out to engulf the microbe and place it in a vesicle called a phagosome. Finally, lysosomes, containing digestive enzymes and microbicidal chemicals, fuse with the phagosome containing the ingested microbe and the microbe is destroyed.


Flash animation illustrating Phagocytosis by Unenhanced Attachment
(PAMPs Binding to Endocytic Pattern-Recognition Receptors).swf
by Gary E. Kaiser, Ph.D.
Professor of Microbiology, The Community College of Baltimore County, Catonsville Campus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at http://faculty.ccbcmd.edu/~gkaiser/index.html.

Creative Commons License

Last updated: August, 2018
Please send comments and inquiries to Dr. Gary Kaiser