Think-Pair-Share Questions

Looking at the overall mechanism for PAMP/PRR/cytokine-induced SIRS as given in your learning object on SIRS that was just covered, answer the following:

1. Define hypotension and describe the biological mechanism behind 2 factors that contribute to hypotension.

2. Define hypovolemia and describe the biological mechanism behind 3 factors that contribute to hypovolemia.

3. Define hypoperfusion and describe the biological mechanism behind 3 factors that contribute to hypoperfusion.

4. Describe the biological mechanism behind ARDS and how ARDS contributes to hypoperfusion.

5. Describe the sequence of events that enables hypoperfusion to lead to irreversible cell damage.

6. What is end-organ ischemia?