BIOL 230 Lecture Guide

Cytokines such as TNF and Il-1 induce the production of selectins, chemokines, and adhesion molecules on the inner surface of the endothelial cells that form the blood vessels. Eventually integrins on the surface of the leukocyte bind to adhesion molecules on the inner surface of the vascular endothelial cells. The leukocytes flatten out and squeeze between the endothelial cells, leaving the blood vessels and entering the tissue.