Binding of Endotoxins to Neutrophils
and Release of Killing Agents
The LPS released from
the gram-negative cell wall binds to LPS receptors on the surface of defense
cells such as monocytes, macrophages and neutrophils. This is a normal component
of body defense and is one of the mechanisms by which the body is able to recognize
that gram-negative bacteria have invaded the body. The
binding of LPS to the LPS receptors and IL-8 to IL-8 receptors on the surface
of neutrophils stimulates them to release proteases and toxic oxygen radicals
for extracellular killing.
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Updated: Jan. 11, 2000
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