Mode of Action of the Tetanus
Exotoxin
Tetanus exotoxin
is a neurotoxin that binds to inhibitory interneurons of the spinal cord
and blocks their release of inhibitors. It is these inhibitors from the
inhibitory interneurons that eventually allow contracted muscles to relax
by stopping excitatory neurons from releasing the acetylcholine that is
responsible for muscle contraction. The toxin, by blocking the release of
inhibitors, keeps the involved muscles in a state of contraction and leads
to spastic paralysis, a condition where opposing flexor and extensor muscles
simultaneously contract.
GIF animation illustrating the mode of action of the tetanus exotoxin .gif by Gary E. Kaiser, Ph.D.
Professor of Microbiology,
The Community College of Baltimore County, Catonsville Campus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://cwoer.ccbcmd.edu/science/microbiology/index_gos.html.
Last updated: August, 2019
Please send comments and inquiries to Dr.
Gary Kaiser