Fig. 4: Capillary Damage during
Systemic Inflammatory Response Syndrome (SIRS)

With the production of large amounts
of proinflammatory cytokines, neutrophils adhere to capillary walls in massive
amounts. Chemokines cause neutrophils to release proteases and toxic oxygen
radicals, the same chemicals they use to kill microbes, but these toxic chemicals
are now being dumped onto the vascular endothelial cells to which the neutrophils
have adhered during diapedesis. This results in damage to the capillary walls
and leakage of blood.
Illustration ofCapillary Damage during
Systemic Inflammatory Response Syndrome (SIRS) .jpg by Gary E. Kaiser, Ph.D.
Professor of Microbiology,
The Community College of Baltimore County, Catonsville Campus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://cwoer.ccbcmd.edu/science/microbiology/index_gos.html.

Last updated: August, 2019
Please send comments and inquiries to Dr.
Gary Kaiser