Self Quiz for Antiviral Agents

Study the material in this section and then write out the answers to these questions.
Do not just click on the answers and write them out. This will not test your understanding of this tutorial.

1. Explain why the antibiotics we use to treat bacterial infections are not effective against viral infections. (ans)

2. Match the following drugs with the viral infections they are used against:

_____ amantadine, rimantidine, zanamivar, and oseltamivir (ans)

_____ acyclovir, famciclovir, penciclovir, and valacyclovir(ans)

_____ foscarnet, gancyclovir, cidofovir, valganciclovir, and fomivirsen(ans)

_____ AZT (ZDV), didanosine, zalcitabine, stavudine, nevirapine, delavirdine, saquinavir, and ritonavir (ans)

a. HIV infection and AIDS
b. influenza A
c. severe CMV infections such as retinitis
d. HSV and VZV infections

3. Match the following:

_____ These are drugs that bind to the active site of an HIV-encoded protease and prevent it from cleaving the long gag-pol polyprotein and the gag polyprotein into essential proteins essential to the structure of HIV and to RNA packaging within its nucleocapsid. As a result, viral maturation does not occur and noninfectious viral particles are produced. (ans)

_____ These drugs chemically resemble normal DNA nucleotides, the building block molecules for DNA synthesis. They bind to the active site of the reverse transcriptase which, in turn, inserts it into the growing DNA strand in place of a normal nucleotide. Once inserted, however, new DNA nucleotides are unable to attach to the drug and DNA synthesis is stopped. This results in an incomplete provirus. (ans)

a. nucleoside reverse transcriptase inhibitors
b. non-nucleoside reverse transcriptase inhibitors
c. protease inhibitors
d. entry inhibitors

4. Multiple Choice (ans)

• RETURN TO "ANTIVIRAL AGENTS"

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