Fig. 3: An Antigen-Presenting Dendritic Cell Presenting MHC-I with Bound Peptide to a Naive T8-Lymphocyte having a Complimentary T-cell Receptor

These APCs can degrade endogenous antigens (those found in the cytosol of the cell) into peptides by way of proteasomes. These peptides are then bound to MHC-I molecules, and placed on the surface of the dendritic cell. Now the peptide/MHC-I complexes can be recognized by a naive T8-lymphocyte having a complementary shaped T-cell receptor (TCR) and CD8 molecule. This activates the naive T8-lymphocyte enabling it to eventually proliferate and differentiate into cytotoxic T-lymphocytes (CTLs).

Illustration of An Antigen-Presenting Dendritic Cell presenting MHC-I with Bound Peptide to a Naive T8-Lymphocyte having a Complimentary T-cell Receptor .jpg by Gary E. Kaiser, Ph.D.
Professor of Microbiology, The Community College of Baltimore County, Catonsville Campus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://cwoer.ccbcmd.edu/science/microbiology/index_gos.html.

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Last updated: Feb., 2021
Please send comments and inquiries to Dr. Gary Kaiser