Fig. 5: An Effector T4-Lymphocyte Recognizing Epitope/MHC-II on an activated B-Lymphocyte and Producing Cytokines to Trigger Proliferation and Differentiation

An effector T4-lymphocyte, such as a TFH cell, use its TCRs and CD4 molecules to bind to a complementary shaped MHC-II molecules with attached peptide epitope on an activated B-lymphocyte. This interaction, along with the binding of co-stimulatory molecules such as CD40 and B7 on the B-lymphocyte with their complementary ligands CD40L and CD28 on the effector T4-lymphocyte triggers the T4-lymphocyte to produce cytokines that enable the activated B-lymphocyte to proliferate, differentiate into antibody-secreting plasma cells, and switch classes of the antibodies being made.

Illustration of An Effector T4-Lymphocyte Recognizing Epitope/MHC-II on an activated B-Lymphocyte and Producing Cytokines to Trigger Proliferation and Differentiations .jpg by Gary E. Kaiser, Ph.D.
Professor of Microbiology, The Community College of Baltimore County, Catonsville Campus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://cwoer.ccbcmd.edu/science/microbiology/index_gos.html.

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Last updated: August, 2019
Please send comments and inquiries to Dr. Gary Kaiser